Hematopoietic Stem Cell Liver Regeneration

Epub 2014 jun 10.

Hematopoietic stem cell liver regeneration.

The stem cell for the liver has been defined as the cell that gives rise to both hepatocytes and biliary epithelial cells cholangiocytes the two types of liver epithelial cells. Hematopoietic stem cells and liver regeneration. 42 the side population cells are hematopoietic stem. 39 40 the normal adult murine liver contains hematopoietic cells that are phenotypically similar to cells present in the bone marrow 41 including cells of the bone marrow side population.

Haematopoiesis is the process by which all mature blood cells are produced. Differentially acting hematopoietic stem cell mobilization agents reverse induced chronic liver injury. Blood cells mol dis. Differentially acting hematopoietic stem cell mobilization agents reverse induced chronic liver injury blood cells mol dis.

Liver cirrhosis is a major cause of mortality and a common end of various progressive liver diseases. 1 10 this regeneration process is governed. Although there are many reports describing liver stem cells the measures used to define liver stem cells have not necessarily been adequate in many cases. In mammals the liver can undergo regeneration after either chemical injury or surgical resection of liver mass a partial hepatectomy ph procedure.

This process occurs in the red bone marrow in the core of most bones in embryonic development the red bone marrow is derived from the layer of the embryo called the mesoderm. 1 10 this regeneration process is governed by dynamic interplay between parenchymal hepatocytes and non parenchymal cells npcs 1 2 4 11 14 including stellate cells 5 10 liver sinusoidal endothelial cells lsecs 15 23. Thus the concept of bone marrow derived liver regeneration has been strongly questioned and the current belief is that the clinical benefit observed in injured tissues after hematopoietic stem cell hsc therapies is produced by the activation of endogenous progenitor cells through paracrine signaling between donor and host cells providing. Stemlike cells positive for cd34 and c kit have been isolated from normal and cirrhotic human livers.

However there is still much to be understood regarding the precise mechanisms of action. Hematopoietic stem cells hscs are the stem cells that give rise to other blood cells this process is called haematopoiesis.